The Ministry of Health through the National Tuberculosis Control Program (NTCP) will be conducting Swaziland’s First National TB Prevalence Survey (2018). The main aim of the study is to measure the national prevalence of bacteriologically-confirmed pulmonary TB among adults aged ≥15 years in Swaziland. This will be undertaken through symptom and x-ray screening of eligible participants at the community level and laboratory testing of presumptive TB cases. Swaziland has been experiencing a significant discrepancy between the annual TB case notifications and the WHO estimates for the country.
Therefore, a TB Prevalence Survey is highly recommended by WHO to illuminate whether or not TB cases are missed by the National TB Control Program (NTCP) and the extent to which people with TB are being treated by providers that are not linked to the NTCP. The results will be used alongside an in-depth analysis of surveillance data and programmatic data, as the basis for a comprehensive update of estimates for TB disease burden (incidence, mortality, and prevalence). The survey is scheduled to begin field operations from May 2018 until October 2018 with preliminary results available in Q1 2019. Community sensitization and mobilization is currently ongoing in mass media and through community leadership engagement with regular feedback to partners and stakeholders. For further details contact National TB Control Program (NTCP).
HIV Prevention Trials Network (HPTN) 084
Study This is a multi-country, multi-site randomized controlled clinical trial exploring the safety and efficacy of long-acting injectable cabotegravir compared to daily oral tenofovir dispoproxil fumarate/emtricitabine for pre-exposure prophylaxis (PrEP) in HIVuninfected women. Approximately 3,600 women in sites from sub-Saharan Africa will be enrolled in the study. Study duration is approximately 4.6 years total, with individual participants being followed on randomized product between 1.6 years (for the last enrolling participants) to approximately 3.6 years (for the earliest enrolling participants), and on open-label oral TDF/TDF for an additional 48 weeks (starting no later than 8 weeks after the last injection for participants randomized to CAB LA). The HPTN 084 (LIFE) study is jointly funded by the U.S. National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, Bill & Melinda Gates Foundation and ViiV Healthcare. Study drugs are provided by ViiV Healthcare and Gilead Sciences, Inc. For further details contact Mbabane FLAS.
Swaziland National TBDrug Resistant Survey2016: Updates
This is an ongoing survey by the National TB Control Program (NTCP)MoH. The study aim to determine the prevalence of MDR-TB and other drug resistance in the country and to describe the types of M-/X-DR TB strains circulating in the country. Study population are all newly diagnosed and previously treated patients diagnosed with pulmonary TB based on Xpert MTB/RIF during the study period and meeting the inclusion criteria. Study sample size is 1008 MTB positive new cases with culture results Recruitment is ongoing in all public health facilities that screen patients for TB exposure and in alll peripheral laboratories that perform Xpert MTB/RIF testing as per the national diagnostic algorithm. For further details contact National TB Control Program (NTCP)
The Evidence for Contraceptive Options and HIV Outcomes (ECHO):Updates
This is an ongoing randomized clinical trial by the Ministry of Health through Sexual Reproductive Health being implemented by FLAS and ICAP. The study aims to evaluate whether use of 3 highly effective, reversible methods of contraception including non-hormonal (family planning methods; Depo Provera, Implant Jadelle and Copper T IUD increases a woman’s risk of getting infected with HIV. Recruitment is in progress. For detailed information on the conduct and participation in the study the public is encouraged to visit FLAS-Manzini further details contact CHAISwaziland.
Effect of Family-Centered Model of HIV Care (FAM-CARE) on Viral Suppression andRetention in Care of HIV-Positive Children inSwaziland
The Ministry of Health and Elizabeth Glaser Pediatric AIDS Foundation (EGPAF) is piloting family-centered service delivery program (FAM-CARE) in selected health facilities in the Hhohho region to provide more efficient and effective services to promote better ART initiation and retention in care for adults and children. Project aim is to evaluate the effectiveness of the pilot FAM-CARE program in retaining children in care and viral